Wednesday, August 1, 2012

0 Qutenza®

 I am in a research project that they will use Qutenza®  that is a patch to be used against nerve pain.
They will use it on my lung scar since that is so painful. The project haven't started yet, but I hope it will show some promise. And  give me some relief that I have longed after for so long. I don't expect it to make my situation good, but if the nerve pain from the scar and in my chest after the lung surgery can be relived with Qutenza®, then I am all for it.
Like I have said before, try everything twice, leave no rock unturned...

Qutenzas main active ingredient is capsaicin which is the active component of chili peppers that gives them their heat sensation.
It is also the  first and only pure, concentrated, synthetic capsaicin prescription drug.
Capsaicin initial effect is the activation of TRPV1-expressing cutaneous nociceptors, which causes stinging and erythema due to release of vasoactive neuropeptides. After capsaicin exposure are cutaneous nociceptors less sensitive to a variety of stimuli. These effects of capsaicin, which occurs at a later stage, often called desensitization and is believed to be underlying the pain relief.
Other sensations such as heat sensitivity are not affected
Qutenza has been shown to be effective used alone and in combination with systemic drugs for neuropathic pain. Pain reduction is seen in clinical trials as early as week 1, and persists in the 12-week study period!

 Qutenza® (capsaicin) should be placed on the intact, undamaged skin by a physician or under the supervision of a physician.(use max. 4 patches per time). The patch will remain on the skin for only 30-60 minutes. Initially the capsaicin empty cells for neurotransmitters that transmit burning pain. This can lead to local irritation, burning / stinging pain after the patch is placed on the skin area to be treated. This area should be treated with local anesthetic cream (lidocaine) to mitigate this reaction before capsaicin patch can be applied.
The first few days after the treatment, the treated area may be sensitive to heat, so avoid hot showers or baths, direct sunlight, and exercising. For persistent or recurrent pain, a new patch is put on every 3 months.

Commonly reported side effects are local transient burning, pain, erythema and itching at the attachment site. The side effects are transient, self-limiting and usually mild to moderate intensity.
Very common (> 1/10): other: pain and erythema application site.
Common (≥ 1/100 to <1/10): other: itching, papules, vesicles, edema, swelling and dryness of application site .
Uncommon (≥ 1/1000 to <1/100): gastrointestinal: nausea. Heart / man: first degree AV block, tachycardia, palpitations. Skin: itching. Hypertension. Infections: Herpes zoster.
Respiratory: cough, throat irritation. Musculoskeletal system: pain in the extremities, muscle spasms.
Nervous system: dysgeusia, hypoesthesia, burning. Investigations: elevated blood pressure. Eye: eye irritation. Rare: urticaria, paresthesias, dermatitis, hyperaesthesia, inflammation, reaction, irritation and bruising  application site. Peripheral edema.

The good thing about living in this socialistic country is that I will get this treatment for free. One patch costs 428.717$, so if I had needed 4 patches each time that would have cost me 1714.86 $ every quarter.
The more time I deal with my situation the more strongly I belive that free health care is a human right, and not for the blessed few who can afford to bye they're health!

0 kommentarer:

Post a Comment